Gene name:
Kdr (Flk-1;Flk1) ;
Protein name:
Vascular endothelial growth factor receptor 2 (VEGFR-2) ;
Alternative:
Kinase NYK ;Fetal liver kinase 1 (FLK-1) ;Protein-tyrosine kinase receptor flk-1 ;
CD:
CD309 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with SHB; upon VEGF activation. Interacts with MYOF.
Function:
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MESKALLAVA | LWFCVETRAA | SVGLPGDFLH | PPKLSTQKDI | LTILANTTLQ |
100:
ITCRGQRDLD | WLWPNAQRDS | EERVLVTECG | GGDSIFCKTL | TIPRVVGNDT |
150:
GAYKCSYRDV | DIASTVYVYV | RDYRSPFIAS | VSDQHGIVYI | TENKNKTVVI |
200:
PCRGSISNLN | VSLCARYPEK | RFVPDGNRIS | WDSEIGFTLP | SYMISYAGMV |
250:
FCEAKINDET | YQSIMYIVVV | VGYRIYDVIL | SPPHEIELSA | GEKLVLNCTA |
300:
RTELNVGLDF | TWHSPPSKSH | HKKIVNRDVK | PFPGTVAKMF | LSTLTIESVT |
350:
KSDQGEYTCV | ASSGRMIKRN | RTFVRVHTKP | FIAFGSGMKS | LVEATVGSQV |
400:
RIPVKYLSYP | APDIKWYRNG | RPIESNYTMI | VGDELTIMEV | TERDAGNYTV |
450:
ILTNPISMEK | QSHMVSLVVN | VPPQIGEKAL | ISPMDSYQYG | TMQTLTCTVY |
500:
ANPPLHHIQW | YWQLEEACSY | RPGQTSPYAC | KEWRHVEDFQ | GGNKIEVTKN |
550:
QYALIEGKNK | TVSTLVIQAA | NVSALYKCEA | INKAGRGERV | ISFHVIRGPE |
600:
ITVQPAAQPT | EQESVSLLCT | ADRNTFENLT | WYKLGSQATS | VHMGESLTPV |
650:
CKNLDALWKL | NGTMFSNSTN | DILIVAFQNA | SLQDQGDYVC | SAQDKKTKKR |
700:
HCLVKQLIIL | ERMAPMITGN | LENQTTTIGE | TIEVTCPASG | NPTPHITWFK |
750:
DNETLVEDSG | IVLRDGNRNL | TIRRVRKEDG | GLYTCQACNV | LGCARAETLF |
800:
IIEGAQEKTN | LEVIILVGTA | VIAMFFWLLL | VILVRTVKRA | NEGELKTGYL |
850:
SIVMDPDELP | LDERCERLPY | DASKWEFPRD | RLKLGKPLGR | GAFGQVIEAD |
900:
AFGIDKTATC | KTVAVKMLKE | GATHSEHRAL | MSELKILIHI | GHHLNVVNLL |
950:
GACTKPGGPL | MVIVEFSKFG | NLSTYLRGKR | NEFVPYKSKG | ARFRQGKDYV |
1000:
GELSVDLKRR | LDSITSSQSS | ASSGFVEEKS | LSDVEEEEAS | EELYKDFLTL |
1050:
EHLICYSFQV | AKGMEFLASR | KCIHRDLAAR | NILLSEKNVV | KICDFGLARD |
1100:
IYKDPDYVRK | GDARLPLKWM | APETIFDRVY | TIQSDVWSFG | VLLWEIFSLG |
1150:
ASPYPGVKID | EEFCRRLKEG | TRMRAPDYTT | PEMYQTMLDC | WHEDPNQRPS |
1200:
FSELVEHLGN | LLQANAQQDG | KDYIVLPMSE | TLSMEEDSGL | SLPTSPVSCM |
1250:
EEEEVCDPKF | HYDNTAGISH | YLQNSKRKSR | PVSVKTFEDI | PLEEPEVKVI |
1300:
PDDSQTDSGM | VLASEELKTL | EDRNKLSPSF | GGMMPSKSRE | SVASEGSNQT |
1350:
SGYQSGYHSD | DTDTTVYSSD | EAGLLKMVDA | AVHADSGTTL | QLTSCLNGSG |
1367:
PVPAPPPTPG | NHERGAA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse VEGFR-2
ELISA Kit for Mouse VEGFR-2
ELISA Kit for Mouse VEGFR-2
CLIA Kit for Mouse VEGFR-2
CLIA Kit for Mouse VEGFR-2
CLIA Kit for Mouse VEGFR-2
Polyclonal Antibody for Mouse VEGFR-2
Polyclonal Antibody for Mouse VEGFR-2
Polyclonal Antibody for Mouse VEGFR-2
Monoclonal Antibody for Mouse VEGFR-2
Monoclonal Antibody for Mouse VEGFR-2
Monoclonal Antibody for Mouse VEGFR-2
Protein for Mouse VEGFR-2
Protein for Mouse VEGFR-2
Protein for Mouse VEGFR-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VEGFA
strain :
BALB/c .
tissue :
Embryo .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
strain :
C3H/He .
tissue :
Fetal liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
4.
"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth."
Albuquerque R.J.
,
Hayashi T.
,
Cho W.G.
,
Kleinman M.E.
,
Dridi S.
,
Takeda A.
,
Baffi J.Z.
,
Yamada K.
,
Kaneko H.
,
Green M.G.
,
Chappell J.
,
Wilting J.
,
Weich H.A.
,
Yamagami S.
,
Amano S.
,
Mizuki N.
,
Alexander J.S.
,
Peterson M.L.
,
Brekken R.A.
,
Hirashima M.
,
Capoor S.
,
Usui T.
,
Ambati B.K.
,
Ambati J.
more...
Nat. Med.15:1023-1030(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH VEGFC;FUNCTION IN INHIBITING VEGFC SIGNALING;SUBCELLULAR LOCATION
strain :
C57BL/6 .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH VEGFA;AUTOPHOSPHORYLATION;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION
8.
"Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution."
Pepper M.S.
,
Baetens D.
,
Mandriota S.J.
,
Di Sanza C.
,
Oikemus S.
,
Lane T.F.
,
Soriano J.V.
,
Montesano R.
,
Iruela-Arispe M.L.
Dev. Dyn.218:507-524(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT TYR-1212;MUTAGENESIS OF TYR-1212
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FLT4;CATALYTIC ACTIVITY
11.
"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1."
Autiero M.
,
Waltenberger J.
,
Communi D.
,
Kranz A.
,
Moons L.
,
Lambrechts D.
,
Kroll J.
,
Plaisance S.
,
De Mol M.
,
Bono F.
,
Kliche S.
,
Fellbrich G.
,
Ballmer-Hofer K.
,
Maglione D.
,
Mayr-Beyrle U.
,
Dewerchin M.
,
Dombrowski S.
,
Stanimirovic D.
,
Van Hummelen P.
,
Dehio C.
,
Hicklin D.J.
,
Persico G.
,
Herbert J.M.
,
Communi D.
,
Shibuya M.
,
Collen D.
,
Conway E.M.
,
Carmeliet P.
more...
Nat. Med.9:936-943(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FLT1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SHB;MUTAGENESIS OF TYR-1173
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CBL;UBIQUITINATION;PHOSPHORYLATION AT TYR-1052 AND TYR-1057;MUTAGENESIS OF LYS-866; SER-1188 AND SER-1191;SUBCELLULAR LOCATION
14.
"Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function."
Bernatchez P.N.
,
Acevedo L.
,
Fernandez-Hernando C.
,
Murata T.
,
Chalouni C.
,
Kim J.
,
Erdjument-Bromage H.
,
Shah V.
,
Gratton J.-P.
,
McNally E.M.
,
Tempst P.
,
Sessa W.C.
J. Biol. Chem.282:30745-30753(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MYOF
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
"Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis."
Nakao S.
,
Zandi S.
,
Hata Y.
,
Kawahara S.
,
Arita R.
,
Schering A.
,
Sun D.
,
Melhorn M.I.
,
Ito Y.
,
Lara-Castillo N.
,
Ishibashi T.
,
Hafezi-Moghadam A.
Blood117:1081-1090(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION